SportsLine golf expert Eric Cohen locked in a $10 eight-leg PGA Tour parlay that would return nearly $1.1 million for the British Open 2025

The simplest one is to wager on the in-form golfers, a list led by Rory McIlroy and Scottie Scheffler. McIlroy may get the nod over Scheffler in some circles this week because he's playing on home soil at Royal Portrush in Northern Ireland.

Brooks Koepka enters play in the 2025 Open Championship at Royal Portrush Golf Club with +5500 odds to win. In his last event at this course he finished fourth in the 2019 The Open Championship. In his four tournaments during the past year, Koepka has a best finish of 12th and an average finish of 28th, with two made cuts.

Latest Open 2025 betting odds - Find the latest Open odds ahead of the 2025 edition taking place at Royal Portrush

But nobody should ever mistake artificial intelligence for being sappy. USA TODAY Sports canvassed five major AI programs seeking their predictions for the 2025 Open Championship winner and top sleeper picks. The majority went with the pre-tournament favorite, Scottie Scheffler, who is seeking his first Claret Jug.

Russell Henley has +6500 odds to win the 2025 Open Championship at Royal Portrush Golf Club as he tries to follow up his fifth-place showing at this tournament in 2024 with another high finish. Henley has one win, and an average finish of 16th, in his 19 events during the past year (including six top fives).

Jason Sobel on the oldest tradition at the Open Championship, betting, and how it is more enjoyable than ever.

Open Championship marks the final major of the year, with Royal Portrush hosting the event for the first time since 2019. Rory McIlroy

Open Championship is only a days away from teeing off. Here are the predictions, odds and how to watch the last major of the year.