Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the ...

Cancer immunotherapy has completely changed our understanding of how cancer can and should be treated. A prime example is chimeric antigen receptor (CAR) T-cell therapy, where T cells are harvested ...

The novel Epitope Binning-seq technology streamlines antibody epitope mapping and enables the simultaneous evaluation of large numbers of genetically encoded antibodies, grouping them into distinct ...

The Single-antigen Bead (SAB) assay has revolutionized the detection of anti-HLA antibodies, which are critical in transplantation medicine. Despite its advantages, several limitations and challenges ...

In a recent study posted to the bioRxiv* preprint server, researchers designed a lentivirus-based mammalian surface-display platform combined with deep mutational scanning (DMS) to evaluate the impact ...

Rapid Novor Inc. and MAbSilico announced that they have partnered to provide the world's first AI-driven HDX-MS epitope mapping service for antibody development. By seamlessly integrating experimental ...

The early identification of antibody candidates with desired affinities and dissociation kinetics, binding epitopes and critical quality attributes is vital for avoiding later-phase failures caused by ...