When a transplanted organ arrives, it’s like a controlled burn that risks becoming a wildfire. The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the ...

Current treatments to prevent organ transplant rejection focus mainly on suppressing T cells, part of the adaptive immune system. However, the innate immune system—the body's first line of defense ...

A man with long-standing type 1 diabetes underwent transplant with UP421 gene-edited islet cells designed to avoid rejection. Even without immunosuppression, the patient remained free of an immune ...

A Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize ...