Local mRNA translation is a post-transcriptional gene regulatory mechanism that enables autonomous control of local proteomes in subcellular compartments. This mechanism operates in neuronal dendrites ...

Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production, a process that fails in amyotrophic lateral sclerosis (ALS). The study, ...

As axonal mitochondria are lost, changes in the subunits of eIF2 are seen which hamper translation and autophagy and cause the accumulation of proteins in cells. Tokyo, Japan – Researchers from Tokyo ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein.

Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

A research team led by investigators at McMaster University has identified an axonal guidance signaling pathway that cancer cells use to infiltrate the brain. The combined results of preclinical in ...

Left: confocal microscopy of a stained brain tissue slice from a rat. Right: the corresponding dMRI slice of the rat’s brain, shown with a voxel-wise map of the MR-derived effective radii. (Courtesy: ...

Giant axonal neuropathy (GAN) is a rare, autosomal recessive neurodegenerative disorder, characterized by a spectrum of symptoms and a challenging prognosis. Now, a study published recently in the New ...

The family of Jules Bianchi, the Formula One racing driver who was critically injured at Sunday’s Japanese Grand Prix, have revealed that he is suffering from a “diffuse axonal injury.” It is a ...