Sustained calcium signaling induces a state of anergy or antigen unresponsiveness in T cells, mediated through calcineurin and the transcription factor NFAT. We show here that Ca 2+-induced anergy is ...

Pimecrolimus and tacrolimus, 2 topical calcineurin inhibitors for the treatment of atopic dermatitis (AD), were not shown to increase the risk of cancer based on moderate-certainty evidence from a ...

Researchers have found in a new study that Lichen sclerosus is linked to a significantly increased risk of vulvar dysplasia ...

Topical calcineurin inhibitors (TCIs) are a type of treatment that alters your immune system. You can use TCIs for atopic eczema. These therapies are “topical,” which means you put them on your skin. ...

Share on Facebook. Opens in a new tab or window Share on Bluesky. Opens in a new tab or window Share on X. Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Topical ...

Please provide your email address to receive an email when new articles are posted on . LOUISVILLE, Ky. — Researchers showed with moderate certainty that topical calcineurin inhibitors did not ...

Am J Health Syst Pharm. 2006;63(23):2340-2348. MDR1 (ABCB1) T-129C, C1236T, G2677(T,A), C3435T No difference observed for cyclosporine and any CYP3A5 polymorphism Wild-type carriers of MDR1 (ABCB1) ...

Dr Dunn leads a discussion outlining frontline therapies for the treatment of vitiligo. Jeffrey D. Dunn, PharmD, MBA: What therapies are being used? Are they generally covered by different books of ...