Fragment-based drug design is a new approach that has been successfully applied to challenging targets, such as protein-protein interactions. While 3-D protein structures have been used in drug ...
Creating new drugs is extremely difficult, and very expensive 1. There are an estimated 10 60 drug-like molecules in chemical space — the theoretical space spanned by all possible molecules and ...
Researchers are increasingly relying upon fragment-based lead discovery in their search for novel and effective drug candidates. The approach utilizes a number of complementary technologies, with ...
New research published in Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral ...
Cancer, diabetes, inflammation, malaria. The list of diseases ripe for new treatments is long. Yet the pace of drugs coming to market is actually flat. A key reason is the drug discovery process ...
A groundbreaking new algorithm called Quantum-assisted Fragment-based Automated Structure Generator (QFASG) from a team of researchers at clinical stage artificial intelligence (AI)-driven biotech ...
New approaches are essential to deliver drugs and tool compounds against increasingly difficult targets. Rather than screening millions of drug-sized compounds, fragment-based drug discovery starts ...
A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) ...
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