JSTOR Daily

Downregulation of pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase activity in sugarcane culms enhances sucrose accumulation due to elevated hexose-phosphate levels

Planta, Vol. 231, No. 3 (February 2010), pp. 595-608 (14 pages) Analyses of transgenic sugarcane clones with 45—95% reduced cytosolic pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase (PFP, ...
Seeking Alpha

Inozyme: Early Rare Disease Data, Decent Cash, No Major Near-Term Catalysts

Inozyme targets rare diseases characterised by pyrophosphate deficiency. It has produced some early positive data. Lead asset INZ-701 may start a pivotal trial this year. Lead asset INZ-701, a novel ...
News Medical

Breakthrough study finds genes behind calcium pyrophosphate deposition disease

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of ...
JSTOR Daily

Tuber Physiology and Properties of Starch from Tubers of Transgenic Potato Plants with Altered Plastidic Adenylate Transporter Activity

Plant Physiology, Vol. 125, No. 4 (Apr., 2001), pp. 1667-1678 (12 pages) We showed recently that antisense plants with decreased activity of the plastidic ATP/ADP-transporter protein exhibit ...
Medscape

New Gene Mutations Found Involved in Arterial Calcification

February 4, 2011 (Bethesda, Maryland) — New gene mutations have been discovered that are thought to be responsible for a rare disease causing extensive calcification of lower-extremity arteries and ...
Nature

Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine–induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats

Both norepinephrine (NE) and connective tissue growth factor (CTGF) contribute to vascular fibrosis during hypertension. Recent studies indicate that farnesyl pyrophosphate synthase (FPPS) plays an ...