Erectile dysfunction (ED) is a common male sexual dysfunction characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse [1, 2]. This condition not only exerts ...

Researchers are merging AI and Mendelian randomization (MR) to accelerate causal inference in biomedical research. New systems like MRAgent and AI-driven GWAS data fetchers automate literature review, ...

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...

Mendelian Randomization (MR) has become an essential tool in psychiatric research offering valuable insights into the causal relationships underlying risks and consequences of psychiatric conditions.

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

The US Food and Drug Administration (FDA) has revised a 2023 draft guidance on master protocols for drug and biological ...

Tesamorelin can selectively reduce visceral fat, as demonstrated in RCTs. But the real story is what it reveals about ...

Breakthrough Designation: Pivotal Trials Lack Randomization, Double-Blinding and Control Groups A review of all therapeutics receiving a breakthrough designation and approved from 2012 to 2017 found a ...

In a randomized clinical trial, instead of allocating patients equally between the treatment arms, some trials in oncology assign a higher proportion of patients to receive the experimental treatment ...

A New York Times health reporter explains what clinical trials are, why they are important and how they can help inform us. Credit...Ricardo Tomás Supported by By Nina Agrawal Nina Agrawal is a health ...

Nirmatrelvir–ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness ...