In a recent study published in Nature Communications, a team of researchers at the Carl R. Woese Institute for Genomic Biology reports a new, robust computational toolset to extract biological ...

The differentiation of post-migratory cranial neural crest cells (CNCCs) into distinct mesenchymal lineages is crucial for craniofacial development. Here we report a high-resolution spatiotemporal ...

This study aims to generate a comprehensive spatial transcriptomic (ST) map of the mouse urinary bladder. While not focused on bladder cancer, we chose the bladder as our primary organ of interest due ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

People communicate with each other, sometimes face to face, sometimes with a text message or phone call. Cells also communicate with each other, sometimes by touching and sometimes by sending signals ...

Foundation models (FMs), which are deep learning models pretrained on large-scale data and applied to diverse downstream tasks, have transformed natural language processing and multimodal AI. However, ...

Larotrectinib in Patients With Tumors With NTRK Fusions: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol EAY131-Z1E Advancements in profiling technologies have deepened our ...

Why do so many promising drugs fail? This article explores how spatial multiomics reveals hidden cell interactions, helping ...

Fei Chen and Chenlei Hu at the Broad Institute of MIT and Harvard have developed a new imaging-free spatial transcriptomics technology that tracks the diffusion of DNA barcodes between beads in an ...

Certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage. Using spatial transcriptomics and AI, ...

In a recent study published in the journal Nature, researchers developed spatial aging clocks using single-cell transcriptomics to explore cell-type-specific interactions and their impact on brain ...

Researchers reveal the intricate molecular landscape of triple-negative breast cancer (TNBC), uncovering actionable spatial archetypes and gene signatures that pave the way for personalized therapies ...