A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy. This ...
An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...
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Newly discovered cellular trigger could lead to possible therapies for Parkinson's disease
Autophagy is essentially the "rubbish collection" of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest ...
AUTOPHAGY IS A hot topic on TikTok, with videos tagged #autophagy racking up nearly 35 million views. People are likely talking so much about autophagy because the subject is closely linked to the ...
Autophagy is essentially the 'rubbish collection' of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest ...
Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.
T. Yorimitsu et al., "Endoplasmic reticulum stress triggers autophagy," J Bio Chem, 281:30299-304, 2006. (Cited in 48 papers) University of Michigan biologist Daniel Klionsky and a group of ...
Upon autophagy induction, ZDHHC13 is recruited to autophagosome formation sites together with ATG9A. ULK1 is palmitoylated at Cys 927 and Cys 1003 residues by ZDHHC13, and the ULK1 complex are ...
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