Israel and Iran have begun a new round of attacks, as the conflict between the two heavily armed rivals enters its fourth day.

U.S. stock futures slipped and oil prices rose on Tuesday, as investors were rattled by U.S. President Donald Trump's call for everyone to evacuate Tehran with the fifth-day of Israel-Iran fighting sowing fears of a broader regional conflict.

Israel faced retaliation from Iran after launching missiles against Tehran's leadership and energy infrastructure as part of "Operation Rising Lion" this weekend. Iran's military responded with a wave of missile strikes against Israel,

In a city under attack, residents encounter gas stations that are closing because there is no fuel, and disruptions to internet and phone service.

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Further strikes from Iran on Israel have left many people killed and dozens injured as the fiery war between the two nations continues. Iran's parliament announced it was preparing a bill that would see exit from the Nuclear Non-Proliferation Treaty as the Israeli military said it has destroyed a third of Iran's surface-to-surface missile launchers.

Israel has no intention of deliberately harming the residents of Tehran, Israeli Defence Minister Israel Katz said, walking back earlier comments he had made on Monday. "I wish to clarify the obvious: there is no intention to physically harm the residents of Tehran as the murderous dictator does to the residents of Israel,

Fresh explosions have been reported in the Iranian capital of Tehran late on Sunday local time after Iran's President warned of "more painful and crushing responses" to Israeli strikes. Footage circulating online on Sunday afternoon Tehran time appear to show smoke rising from buildings in several locations.