Minocycline is broadly protective in neurologic disease models featuring cell death and is being evaluated in clinical trials. We previously demonstrated that minocycline-mediated protection against ...

Scientists from Trinity College Dublin day they have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. The researchers have uncovered a ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

This is a preview. Log in through your library . Abstract Activation of aspartate-specific cysteine proteases (caspases) plays a crucial role in programmed cell death (PCD) in animals. Although to ...

Mitochondria, the “powerhouses of the cell,” are vital cellular organelles that govern energy metabolism, maintain redox ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...

Caspases are best known for their essential role in cell death, but they also play important roles in living cells. How can caspases act inside a cell without accidentally killing it? The Tango7 ...

A new research study has found out that the Caspases, enzymes involved in cell death process, are very important for delivering trim and motile sperms. They have been found to assist in the ...

An agent that inhibits the protease enzyme caspase-6 in a totally new way could help lead to a novel type of medication for Alzheimer’s disease, a condition in which caspase-6 may play a key role.

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Researchers recognize CASP4/11 as ...