Apr 2, 2025 · In 8–13% of individuals with NF1, PN can transform into malignant peripheral nerve sheath tumors (MPNSTs), a type of nerve soft tissue sarcoma that is the main cause of …

Dec 11, 2025 · Although not exclusively focused on NF-related conditions, NCI-GDC comprises NF1 and MPNST samples along with molecular and omics profiles, offering valuable …

Successful curative treatment of MPNST is mainly reliant on a complete surgical resection before metastasis. Failure to completely remove a high- grade MPNST leaves a very poor prognosis …

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients with...

Our goal is to define dynamic gene regulatory networks and microenvironment niche for driving malignant transformation of NF and identify therapeutic targets of MPNST using pre-clinical …

Nov 14, 2019 · Two recent studies, also based on preclinical data using the Nf1;p53 -deficient mouse model, were performed in patients with NF1-associated and sporadic MPNST using a …

May 11, 2025 · Patients without Neurofibromatosis type 1 (NF1) tend to have better outcomes than those with NF1-associated MPNST, as NF1-related tumors are more likely to be …

Jan 1, 2025 · By discussing the modeling methods of cells and animals, we intended to identify the common origin of different types of neurofibroma cells and analyze the developmental …

Jul 2, 2024 · MPNST constitutes the main cause of morbidity and mortality in patients with the inherited condition of neurofibromatosis type-1 (NF1) [3]. MPNSTs often exhibit extensive …

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