Apr 15, 2025 · A tophus (Latin for “stone”) is a large crystal that’s become a granuloma. Tophi happen when hyperuricemia builds up to high levels, which usually means it’s gone untreated. …

Jun 27, 2023 · A tophus (plural: tophi) happens when crystals of the compound known as sodium urate monohydrate, or uric acid, builds up around your joints.

A tophus (Latin: "stone", pl.: tophi) is a deposit of monosodium urate crystals in people with longstanding high levels of uric acid (urate) in the blood, a condition known as hyperuricemia.

Oct 21, 2025 · The skin that lies over a tophus often becomes taut and eventually ulcerates, releasing a soft, white material made of hardened uric acid. The formation of these mineralized …

Jul 20, 2025 · Over time, the immune system may wall off these crystal clusters, forming an inflammatory nodule called a tophus. This process occurs slowly, often taking ten years or …

Dec 29, 2023 · Tophus is a term often associated with gout, a type of arthritis that affects millions of people worldwide. But what exactly is tophus? In simple terms, it is a deposit of uric acid …

The tophus is a hallmark feature of advanced gout and appears clinically as a palpable nodule within subcutaneous tissues, joints, or tendons.

Tophi are a common characteristic of uncontrolled gout. Tophi are stone-like deposits of monosodium urate crystals that accumulate in the soft-tissues, synovial tissues, or bones near …

Mar 15, 2025 · Tophi (plural of tophus) usually appear as lumps on the skin over affected joints due to deposits of monosodium urate crystals in patients with longstanding high levels of …

A tophus (plural, tophi) is a large deposit of uric acid crystals. They appear when hyperuricemia (high levels of uric acid in the blood) turns into gout