PARP Inhibitor Mechanisms of Resistance
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SOLVED: The use of PARP inhibitors in BRCA-mutated breast and ovariancancers represents a strong proof of principle for “syntheticlethality” as a basis for improved therapy. In this context, whichis the best explanation for the efficacy seen clinically whencytotoxic agents are used in combination with PARP inhibitors? a.BRCA deficiencies in DNA repair become lethal when a second repairpathway is also disrupted, and DNA-damaging chemotherapy ispresent. b. PARP inhibitors are metabolically activat
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